Understanding Aripiprazole Dosage for Bipolar Disorder

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Bipolar disorder is a mental health condition that causes extreme mood swings, including episodes of mania and depression. It is a lifelong illness that requires ongoing management.

Aripiprazole is often given to people with bipolar disorder, but it’s important to know how much to take for it to work.

Key takeaways

  • Aripiprazole is used for acute mania or episodes with mixed features, acute hypomania, and maintenance treatment as monotherapy or adjunctive therapy.
  • The initial dose is 10 to 15 mg once daily, which may be increased by 5 to 10 mg/day increments at intervals of ≥1 week up to a maximum of 30 mg/day.
  • Some experts suggest higher initial doses of up to 30 mg/day.
  • The injectable suspension is an alternative agent, and the oral form should be established for tolerability prior to initiation of ER injection.
  • If a dose is missed, the next dose should be administered as soon as possible, and oral aripiprazole may be administered during initiation of the ER injection.

Oral dosage for bipolar disorder

Aripiprazole is used to treat sudden episodes of mania or mixed symptoms, sudden episodes of hypomania, and long-term treatment.

For initial treatment, the recommended dosage is 10 to 15 mg once daily, with the dose increasing in 5 to 10 mg/day increments at intervals of ≥1 week based on response and tolerability, up to a maximum of 30 mg/day. Some experts suggest higher initial doses of up to 30 mg per day.

I njectable suspension dosage for bipolar disorder

Aripiprazole ER injectable suspension is an alternative agent for bipolar disorder. Oral aripiprazole should be established for tolerability before initiating the ER injection.

For a single injection start, 400 mg should be administered once monthly, with doses separated by ≥26 days. Oral aripiprazole or another oral antipsychotic should be taken for 14 days while the ER injection is being given.

For a double injection start, a single oral aripiprazole dose of 20 mg should be administered, plus two 400-mg injections in separate injection sites.

The maintenance dosage is 400 mg once monthly, with doses separated by ≥ 26 days.

Dosage adjustment for adverse effects

For side effects, you might want to lower the ER injection dose to 300 mg once a month.

Missed doses of ER injection

For missed doses of the ER injection, the next dose should be administered as soon as possible if it has been <4 weeks since the last dose.

If it has been >4 weeks but <5 weeks since the last dose, the next dose should be administered as soon as possible.

If it has been >5 weeks since the last dose, oral aripiprazole should be administered for 14 days with the next injection, or a single oral aripiprazole dose of 20 mg should be administered with two aripiprazole 400 mg IM injections in separate injection sites.

The oral dose should be adjusted as needed based on response and tolerability.

For missed doses of the fourth or subsequent doses, the next dose should be administered as soon as possible if it has been <4 weeks since the last dose.

If it has been >4 weeks but <6 weeks since the last dose, the next dose should be administered as soon as possible.

If it has been >6 weeks since the last dose, oral aripiprazole should be administered for 14 days with the next injection, or a single oral aripiprazole dose of 20 mg should be administered with two aripiprazole 400 mg IM injections in separate injection sites.

The oral dose should be adjusted as needed based on response and tolerability.

Conclusion

Proper dosage is essential for the effectiveness of aripiprazole for the treatment of bipolar disorder.

It is recommended to start with an initial dose of 10 to 15 mg once daily, with the dose increasing gradually based on response and tolerability.

Aripiprazole ER injectable suspension is an alternative agent for bipolar disorder, and the oral aripiprazole should be established for tolerability before initiating the ER injection.

The missed doses of the ER injection should be handled with caution, and the oral dose should be adjusted as needed based on response and tolerability. Understanding these details

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